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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012
摘要
To create an HIV-1 vaccine that generates sufficient breadth of 免疫 recognition to protect against the 遺傳ally diverse forms of the circulating 病毒, we have been exploring vaccines based on consensus and mosaic 蛋白質 designs. Increasing the valency of a mosaic immunogen cocktail increases epitope coverage but with diminishing returns, as increasingly rare epitopes are incorporated into the mosaic 蛋白質s. In this study we compared the immunogenicity of 2-valent and 3-valent HIV-1 envelope mosaic immunogens in rhesus monkeys. Immunizations with the 3-valent mosaic immunogens resulted in a modest increase in the breadth of vaccine-elicited T lymphocyte responses compared to the 2-valent mosaic immunogens. However, the 3-valent mosaic immunogens elicited significantly higher neutralizing responses to
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