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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012
摘要
Transfer RNAs (tRNAs) are present in all types of cells as well as in organelles. tRNAs of animal mitochondria show a low level of primary sequence conservation and exhibit 'bizarre' secondary structures, lacking complete domains of the common cloverleaf. Such sequences are hard to detect and hence frequently missed in 計算 analyses and mitochondrial 基因組 annotation. Here, we introduce an automatic annotation procedure for mitochondrial tRNA genes in Metazoa based on sequence and structural 資訊 in manually curated covariance models. The method, applied to re-annotate 1876 available metazoan mitochondrial RefSeq 基因組s, allows to distinguish between remaining functional genes and degrading 'pseudogenes', even at early stages of divergence. The subsequent analysis of a comprehensive set of mitocho
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