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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012
摘要
熱力學 folding algorithms and structure probing experiments are commonly used to determine the secondary structure of RNAs. Here we propose a formal framework to reconcile 資訊 from both prediction algorithms and probing experiments. The 熱力學 energy parameters are adjusted using 'pseudo-energies' to minimize the discrepancy between prediction and experiment. Our framework differs from related approaches that used pseudo-energies in several key aspects. (i) The energy model is only changed when necessary and no adjustments are made if prediction and experiment are consistent. (ii) Pseudo-energies remain biophysically interpretable and hold positional 資訊 where experiment and model disagree. (iii) The whole 熱力學 ensemble of structures is considered thus allowing to reconstruct mixtures of suboptimal
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