本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。
原文連結
論文資訊
- 類型：已發表論文
- 日期：2012
摘要
自然選擇 drives 族群s of individuals towards local peaks in a 適應度景觀. These peaks are created by the interactions between individual 突變s. 適應度景觀s may change as an environment changes. In a previous contribution, we discovered a variant of the Azoarcus group I ribozyme that represents a local peak in the RNA 適應度景觀. The genotype at this peak is distinguished from the wild-type by four point 突變s. We here report ribozyme fitness data derived from constructing all possible combinations of these point 突變s. We find that these 突變s interact epistatically. Importantly, we show that these epistatic interactions change qualitatively in the three different environments that we studied. We find examples where the relative fitness of a ribozyme can change from neutral or negative in one environment, to positive
※ 此為已發表論文，全文需透過期刊付費取得