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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012-01-11
摘要
A potential drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs is the ease with which 病毒es may generate escape 突變s. Using a variation of the classic Luria-Delbruck fluctuation assay, we estimated that the spontaneous 突變 rate in the artificial microRNA (amiR) target of a plant 病毒 was ca.6 x 10(-5) per replication event.
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