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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012-08-23
摘要
A precise molecular identification of transmitted hepatitis C 病毒 (HCV) 基因組s could illuminate key aspects of 傳播 biology, immunopathogenesis and natural history. We used single 基因組 sequencing of 2,922 half or quarter 基因組s from plasma viral RNA to identify transmitted/founder (T/F) 病毒es in 17 subjects with acute community-acquired HCV infection. Sequences from 13 of 17 acute subjects, but none of 14 chronic controls, exhibited one or more discrete low 多樣性 viral lineages. Sequences within each lineage generally revealed a star-like phylogeny of 突變s that coalesced to unambiguous T/F viral 基因組s. Numbers of transmitted 病毒es leading to productive clinical infection were estimated to range from 1 to 37 or more (median = 4). Four acutely infected subjects showed a distinctly different pattern of 病毒
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