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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012-09-06
摘要
About 2000 completely sequenced mitochondrial 基因組s are available from the NCBI Re fSeq data base together with manually curated annotations of their 蛋白質-coding genes, rRNAs, and tRNAs. This annotation 資訊, which has accumulated over two decades, has been obtained with a diverse set of 計算 tools and annotation strategies. Despite all efforts of manual curation it is still plagued by misassignments of reading directions, erroneous gene names, and missing as well as false positive annotations in particular for the RNA genes. Taken together, this causes substantial problems for fully automatic pipelines that aim to use these data comprehensively for studies of animal 系統發育s and the molecular 演化 of mito基因組s. The MITOS pipeline is designed to compute a consistent de novo annotation of the mitogenom
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