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原文連結
論文資訊
- 類型：已發表論文
- 日期：2013
摘要
Structural characteristics are essential for the functioning of many noncoding RNAs and cis-regulatory elements of mRNAs. SNPs may disrupt these structures, interfere with their molecular function, and hence cause a phenotypic effect. RNA folding algorithms can provide detailed insights into structural effects of SNPs. The global measures employed so far suffer from limited accuracy of folding programs on large RNAs and are 計算ly too demanding for 基因組-wide applications. Here, we present a strategy that focuses on the local regions of maximal structural change between mutant and wild-type. These local regions are approximated in a screening mode that is intended for 基因組-wide applications. Furthermore, localized regions are identified as those with maximal discrepancy. The 突變 effects are quan
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