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原文連結
論文資訊
- 類型：已發表論文
- 日期：2013
摘要
Bromodeoxyuridine (BrdU) is widely used in immunology to detect cell division, and several 數學 models have been proposed to estimate proliferation and death rates of lymphocytes from BrdU labelling and de-labelling curves. One problem in interpreting BrdU data is explaining the de-labelling curves. Because shortly after label withdrawal, BrdU(+) cells are expected to divide into BrdU(+) daughter cells, one would expect a flat down-slope. As for many cell types, the fraction of BrdU(+) cells decreases during de-labelling, previous 數學 models had to make debatable assumptions to be able to account for the data. We develop a mechanistic model tracking the number of divisions that each cell has undergone in the presence and absence of BrdU, and allow cells to accumulate and dilute their BrdU con
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