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原文連結
論文資訊
- 類型：已發表論文
- 日期：2013
摘要
Human immunodeficiency 病毒 type 1 (HIV-1) vaccine development requires selection of appropriate envelope (Env) immunogens. Twenty HIV-1 Env glyco蛋白質s were examined for their ability to bind human anti-HIV-1 monoclonal antibodies (MAbs) and then used as immunogens in guinea pigs to identify promising immunogens. These included five Envs derived from chronically infected individuals, each representing one of five common clades and eight consensus Envs based on these five clades, as well as the consensus of the entire HIV-1 M group, and seven transmitted/founder (T/F) Envs from clades B and C. Sera from immunized guinea pigs were tested for neutralizing activity using 36 HIV-1 Env-pseudotyped 病毒es. All Envs bound to CD4 binding site, membrane-proximal, and V1/V2 MAbs with similar apparent affi
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