本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。
原文連結
論文資訊
- 類型：已發表論文
- 日期：2013
摘要
Influenza A (H3N2) offers a well-studied, yet not fully understood, 疾病 in terms of the interactions between pathogen 族群 dynamics, 流行病學 and 遺傳s. A major open question is why the 病毒 族群 is globally dominated by a single and very recently diverged (2-8 years) lineage. Classically, this has been modeled by limiting the generation of new successful antigenic variants, such that only a small subset of progeny acquire the necessary 突變s to evade host immunity. An alternative approach was recently suggested by Recker et al. in which a limited number of antigenic variants are continuously generated, but most of these are suppressed by pre-existing host 族群 immunity. Here we develop a framework spanning the regimes described above to explore the impact of rates of 突變 and levels of competition on phylod
※ 此為已發表論文，全文需透過期刊付費取得