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原文連結
論文資訊
- 類型：已發表論文
- 日期：2013
摘要
It was recently shown that the expansion of CD4(+) T cells during a primary 免疫 reaction to a peptide from cytochrome c decreases similar to 0.5 log for every log increase in the number of cognate precursor cells, and that this remains valid over more than four orders of magnitude (Quiel et al. 2011. Proc. Natl. Acad. Sci. USA. 108: 3312-3317). This observed "冪次定律" was explained by a mechanism where nondividing mature T cells inhibit the proliferation of less-differentiated cells of the same specificity. In this article, we interpret the same data by a mechanism where CD4(+) T cells acquire cognate peptide-MHC (pMHC) complexes from the surface of APCs, thereby increasing the loss rate of pMHC. We show that a 數學 model implementing this "T cell grazing" mechanism, and having a T cell prolifer
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