摘要 Previously we proposed two simplified models of e

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論文資訊

• 類型：已發表論文
• 日期：2013

摘要

Previously we proposed two simplified models of early HIV-1 演化. Both showed that under a model of neutral 演化 and exponential growth, the mean Hamming distance (HD) between 遺傳 sequences grows linearly with time. In this paper we describe a more realistic continuous-time, age-dependent 數學 model of infection and viral replication, and show through simulations that even in this more complex description, the mean Hamming distance grows linearly with time. This remains unchanged when we introduce recombination, though the confidence intervals of the mean HD obtained ignoring recombination are overly conservative.

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