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原文連結
論文資訊
- 類型：已發表論文
- 日期：2013
摘要
The phenotypes of 生物 systems are to some extent robust to genotypic changes. Such robustness exists on multiple levels of 生物 organization. We analyzed this robustness for two categories of amino acids in 蛋白質s. Specifically, we studied the codons of amino acids that bind or do not bind small molecular ligands. We asked to what extent codon changes caused by 突變 or mistranslation may affect physicochemical amino acid properties or 蛋白質 folding. We found that the codons of ligand-binding amino acids are on average more robust than those of non-binding amino acids. Because mistranslation is usually more frequent than 突變, we speculate that selection for error mitigation at the translational level stands behind this phenomenon. Our observations suggest that 自然選擇 can affect the robustness of very s
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