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原文連結
論文資訊
- 類型：已發表論文
- 日期：2013
摘要
Unraveling the structure of complex 生物 網絡s and relating it to their functional role is an important task in systems biology. Here we attempt to characterize the functional organization of the large-scale metabolic 網絡s of three microorganisms. We apply flux balance analysis to study the optimal growth states of these organisms in different environments. By investigating the differential usage of reactions across flux patterns for different environments, we observe a striking bimodal distribution in the activity of reactions. Motivated by this, we propose a simple algorithm to decompose the metabolic 網絡 into three sub網絡s. It turns out that our reaction classifier, which is blind to the biochemical role of pathways, leads to three functionally relevant sub網絡s that correspond to input, output,
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