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原文連結
論文資訊
- 類型：已發表論文
- 日期：2013
摘要
演化ary theory predicts that once an individual reaches an age of sufficiently low Darwinian fitness, (s)he will have reduced chances of keeping 癌症ous lesions in check. While we clearly need to better understand the 湧現 of precursor states and early malignancies as well as their mitigation by the microenvironment and tissue architecture, we argue that lifestyle changes and preventive therapies based in an 演化ary framework, applied to identified high-risk 族群s before incipient neoplasms become clinically detectable and chemoresistant lineages emerge, are currently the most reliable way to control or eliminate early tumours. Specifically, the relatively low levels of (epi)遺傳 heterogeneity characteristic of many if not most incipient lesions will mean a relatively limited set of possible adaptive
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