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原文連結
論文資訊
- 類型：已發表論文
- 日期：2013-07-11
摘要
The molecular chaperone Hsp90 is essential in eukaryotes, in which it facilitates the folding of developmental regulators and signal transduction 蛋白質s known as Hsp90 clients. In contrast, Hsp90 is not essential in 細菌, and a broad characterization of its molecular and organismal function is lacking. To enable such characterization, we used a 基因組-scale 系統發育 analysis to identify genes that co-evolve with 細菌l Hsp90. We find that genes whose gain and loss were coordinated with Hsp90 throughout 細菌l 演化 tended to function in flagellar assembly, chemotaxis, and 細菌l secretion, suggesting that Hsp90 may aid assembly of 蛋白質 complexes. To add to the limited set of known 細菌l Hsp90 clients, we further developed a 統計 method to predict putative clients. We validated our predictions by demonstrating that th
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