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原文連結
論文資訊
- 類型：已發表論文
- 日期：2013-07-15
摘要
抗生素 resistance is becoming increasingly problematic for the treatment of infectious 疾病 in both humans and livestock. The bacterium Pseudomonas aeruginosa is often found to be resistant to multiple 抗生素s and causes high patient mortality in hospitals. Bacteriophages represent a potential option to combat pathogenic 細菌 through their application in phage therapy. Here, we capitalize on previous studies showing how 演化 may increase phage infection capacity relative to ancestral genotypes. We passaged four different phage isolates (podoviridae, myoviridae) through six serial transfers on the ancestral strain of Pseudomonas aeruginosa PAO1. We first demonstrate that repeated serial passage on ancestral 細菌 increases infection capacity of bacteriophage on ancestral hosts and on those evolved for one
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