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原文連結
論文資訊
- 類型：已發表論文
- 日期：2013-08-05
摘要
Objective基因組-wide association studies (GWAS) and their subsequent meta-analyses have changed the landscape of 遺傳s in rheumatoid arthritis (RA) by uncovering several novel genes. Such studies are heavily weighted by samples from Caucasian 族群s, but they explain only a small proportion of total heritability. Our previous studies in 遺傳ally distinct North Indian RA cohorts have demonstrated apparent allelic/遺傳 heterogeneity between North Indian and Western 族群s, warranting GWAS in non-European 族群s. We undertook this study to detect additional 疾病-associated loci that may be collectively important in the presence or absence of genes with a major effect. MethodsHigh-quality genotypes for >600,000 single-nucleotide polymorphisms (SNPs) in 706 RA patients and 761 controls from North India were genera
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