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原文連結
論文資訊
- 類型：已發表論文
- 日期：2013-10-24
摘要
Ribosomal and small nuclear RNAs (snRNAs) comprise numerous modified nucleotides. The modification patterns are retained during 演化, making it even possible to project them from yeast onto human. The stringent conservation of modification sites and the slow 演化 of rRNAs and snRNAs contradicts the rapid 演化 of small nucleolar RNA (snoRNA) sequences. To explain this discrepancy, we investigated the co演化 of snoRNAs and their targeted sites throughout vertebrates. To measure and evaluate the conservation of RNA-RNA interactions, we defined the interaction conservation index (ICI). It combines the quality of individual interaction with the scope of its conservation in a set of 物種 and serves as an efficient measure to evaluate the conservation of the interaction of snoRNA and target. We show that f
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