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原文連結
論文資訊
- 類型：已發表論文
- 日期：2013-12-01
摘要
Background: Identification of the epitopes targeted by antibodies that can neutralize diverse HIV-1 strains can provide important clues for the design of a preventative vaccine. Methods: We have developed a 計算 approach that can identify key amino acids within the HIV-1 envelope glyco蛋白質 that influence sensitivity to broadly cross-neutralizing antibodies. Given a sequence alignment and neutralization titers for a panel of 病毒es, the method works by fitting a 系統發育 model that allows the amino acid frequencies at each site to depend on neutralization sensitivities. Sites at which viral 演化 influences neutralization sensitivity were identified using Bayes factors (BFs) to compare the fit of this model to that of a null model in which sequences evolved independently of antibody sensitivity. Confor
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