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原文連結
論文資訊
- 類型：已發表論文
- 日期：2014
摘要
Background: Latent phenotypes are non-adaptive byproducts of adaptive phenotypes. They exist in 生物 systems as different as promiscuous enzymes and 基因組-scale metabolic reaction 網絡s, and can give rise to 演化ary 適應s and innovations. We know little about their prevalence in the gene expression phenotypes of regulatory circuits, important sources of 演化ary innovations. Results: Here, we study a space of more than sixteen million three-gene model regulatory circuits, where each circuit is represented by a genotype, and has one or more functions embodied in one or more gene expression phenotypes. We find that the majority of circuits with single functions have latent expression phenotypes. Moreover, the set of circuits with a given spectrum of functions has a repertoire of latent phenotypes that is
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