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原文連結
論文資訊
- 類型：已發表論文
- 日期：2014-02-05
摘要
Aquifex aeolicus is a deep-branching hyperthermophilic chemoauto營養級 bacterium restricted to hydrothermal vents and hot springs. These characteristics make it an excellent model system for studying the early 演化 of 代謝. Here we present the whole-基因組 metabolic 網絡 of this organism and examine in detail the driving forces that have shaped it. We make extensive use of phylometabolic analysis, a method we recently introduced that generates trees of metabolic phenotypes by integrating 系統發育 and metabolic constraints. We reconstruct the 演化 of a range of metabolic sub-systems, including the reductive citric acid (rTCA) cycle, as well as the biosynthesis and functional roles of several amino acids and cofactors. We show that A. aeolicus uses the reconstructed ancestral pathways within many of these sub
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