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原文連結
論文資訊
- 類型：已發表論文
- 日期：2014-02-19
摘要
生物 systems perform computations at multiple scales and they do so in a robust way. Engineering metaphors have often been used in order to provide a rationale for modeling cellular and molecular computing 網絡s and as the basis for their synthetic design. However, a major constraint in this mapping between electronic and wet 計算 circuits is the wiring problem. Although wires are identical within electronic devices, they must be different when using synthetic biology designs. Moreover, in most cases the designed molecular systems cannot be reused for other functions. A new approximation allows us to simplify the problem by using synthetic cellular consortia where the output of the computation is distributed over multiple engineered cells. By evolving circuits in silico, we can obtain the minima
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