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原文連結
論文資訊
- 類型：已發表論文
- 日期：2014-04-09
摘要
The distribution of 突變al fitness effects (DMFE) is crucial to the 演化ary fate of quasi物種. In this article we analyze the effect of the DMFE on the dynamics of a large quasi物種 by means of a phenotypic version of the classic Eigen's model that incorporates beneficial, neutral, deleterious, and lethal 突變s. By parameterizing the model with available experimental data on the DMFE of Vesicular stomatitis 病毒 (VSV) and Tobacco etch 病毒 (TEV), we found that increasing 突變 does not totally push the entire viral quasi物種 towards deleterious or lethal regions of the phenotypic sequence space. The probability of finding regions in the parameter space of the general model that results in a quasi物種 only composed by lethal phenotypes is extremely small at equilibrium and in transient times. The implications o
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