本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。
原文連結
論文資訊
- 類型：已發表論文
- 日期：2014-05-14
摘要
An effective HIV-1 vaccine should elicit sufficient breadth of 免疫 recognition to protect against the 遺傳ally diverse forms of the circulating 病毒. Evaluation of the breadth and magnitude of cellular 免疫 responses to epitope variants is important for HIV-1 vaccine assessment. We compared HIV-1 Gag-specific T-lymphocyte responses in 20 HIV-1-infected individuals representing two different HIV-1 subtypes, B and C. By assessing T lymphocyte responses with peptides based on natural HIV-1 variants, we found evidence for limited cross-reactivity and significantly enhanced within-clade responses among clade B-infected subjects, and not among clade C-infected subjects.
※ 此為已發表論文，全文需透過期刊付費取得