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原文連結
論文資訊
- 類型：已發表論文
- 日期：2014-06-06
摘要
The comprehensive understanding of mitochondrial 基因組 演化 requires a detailed mechanistic picture of mitogenomic replication. Despite many previous efforts it has remained a non-trivial problem to determine the origins of replication and trace their fate across rearrangements of the gene order even in the small 基因組s of animal mitochondria We elaborate here on the observation that the GC skew is correlated with the distance from the replication origins. This effect has been explained as a consequence of the standard model of mitochondrial DNA replication, i.e. the strand displacement model. According to this model chemical damage accumulates proportional to the duration that DNA is exposed in single-stranded form during replication (D-ssh) which depends on the relative position with respect t
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