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原文連結
論文資訊
- 類型：已發表論文
- 日期：2014-06-09
摘要
Genotype 網絡s are a concept used in systems biology to study sets of genotypes having the same phenotype, and the ability of these to bring forth novel phenotypes. In the past they have been applied to determine the 遺傳 heterogeneity, and stability to 突變s, of systems such as metabolic 網絡s and RNA folds. Recently, they have been the base for reconciling the neutralist and selectionist views on 演化. Here, we adapted this concept to the study of 族群 遺傳s data. Specifically, we applied genotype 網絡s to the human 1000 基因組s dataset, and analyzed 網絡s composed of short haplotypes of Single Nucleotide Variants (SNV). The result is a scan of how properties related to 遺傳 heterogeneity and stability to 突變s are distributed along the human 基因組. We found that genes involved in acquired immunity, such as some H
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