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原文連結
論文資訊
- 類型：已發表論文
- 日期：2014-07-16
摘要
免疫 escape 突變s that revert back to the consensus sequence frequently occur in newly HIV-1-infected individuals and have been thought to render the 病毒es more fit. However, their impact on viral fitness and their interaction with other 免疫 escape 突變s have not been evaluated in the background of their cognate transmitted/founder (T/F) viral 基因組s. To precisely determine the role of reversion 突變s, we introduced reversion 突變s alone or together with CD8(+) T cell escape 突變s in their unmodified cognate T/F viral 基因組 and determined their impact on viral fitness in primary CD4(+) T cells. Two reversion 突變s, V247I and I64T, were identified in Gag and Tat, respectively, but neither had measurable effect on the fitness of their cognate T/F 病毒. The V247I and G248A 突變s that were detected before and concurr
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