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論文資訊
- 類型：已發表論文
- 日期：2014-07-31
摘要
Human APOBEC3 蛋白質s are cytidine deaminases that contribute broadly to innate immunity through the control of exogenous retro病毒 replication and endogenous retroelement retrotransposition. As an intrinsic antiretroviral defense mechanism, APOBEC3 蛋白質s induce extensive guanosine-to-adenosine (G-to-A) mutagenesis and inhibit synthesis of nascent human immunodeficiency 病毒-type 1 (HIV-1) cDNA. Human APOBEC3 蛋白質s have additionally been proposed to induce infrequent, potentially non-lethal G-to-A 突變s that make subtle contributions to sequence diversification of the viral 基因組 and 適應 though acquisition of beneficial 突變s. Using single-cycle HIV-1 infections in culture and highly parallel DNA sequencing, we defined trinucleotide contexts of the edited sites for APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC
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