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原文連結
論文資訊
- 類型：已發表論文
- 日期：2014-08-08
摘要
The cell cycle genes homology region (CHR) has been identified as a DNA element with an important role in transcriptional regulation of late cell cycle genes. It has been shown that such genes are controlled by DREAM, MMB and FOXM1-MuvB and that these 蛋白質 complexes can contact DNA via CHR sites. However, it has not been elucidated which sequence variations of the canonical CHR are functional and how frequent CHR-based regulation is utilized in mammalian 基因組s. Here, we define the spectrum of functional CHR elements. As the basis for a 計算 meta-analysis, we identify new CHR sequences and compile 系統發育 motif conservation as well as 基因組-wide 蛋白質-DNA binding and gene expression data. We identify CHR elements in most late cell cycle genes binding DREAM, MMB, or FOXM1-MuvB. In contrast, Myband fork
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