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原文連結
論文資訊
- 類型：已發表論文
- 日期：2014-08-13
摘要
Unstable dynamics characterizes the 演化 of most solid tumors. Because of an increased failure of maintaining 基因組 integrity, a cumulative increase in the levels of gene 突變 and loss is observed. Previous work suggests that instability thresholds to 癌症 progression exist, defining 相變 phenomena separating tumor-winning scenarios from tumor extinction or coexistence phases. Here we present an integral equation approach to the quasi物種 dynamics of unstable 癌症. The model exhibits two main phases, characterized by either the success or failure of 癌症 tissue. Moreover, the model predicts that tumor failure can be due to either a reduced selective advantage over healthy cells or excessive instability. We also derive an approximate, analytical solution that predicts the front speed of aggressive tumor 族群
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