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原文連結
論文資訊
- 類型：已發表論文
- 日期：2014-08-21
摘要
Neutralizing antibodies (nAbs) are a high priority for vaccines that aim to prevent the acquisition of HIV-1 infection. Vaccine effectiveness will depend on the extent to which induced antibodies neutralize the global 多樣性 of circulating HIV-1 variants. Using large panels of 遺傳ally and geographically diverse HIV-1 Env-pseudotyped 病毒es and chronic infection plasma samples, we unambiguously show that cross-clade nAb responses are commonly induced in response to infection by any 病毒 clade. Nonetheless, neutralization was significantly greater when the plasma clade matched the clade of the 病毒 being tested. This within-clade advantage was diminished in older, more-diverse 流行病學cs in southern Africa, the United States, and Europe compared to more recent 流行病學cs in Asia. It was most pronounced for ci
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