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原文連結
論文資訊
- 類型：已發表論文
- 日期：2014-09-11
摘要
Background: Large RNA molecules are often composed of multiple functional domains whose spatial arrangement strongly influences their function. Pre-mRNA splicing, for instance, relies on the spatial proximity of the splice junctions that can be separated by very long introns. Similar effects appear in the processing of RNA 病毒 基因組s. Albeit a crude measure, the distribution of spatial distances in 熱力學 equilibrium harbors useful 資訊 on the shape of the molecule that in turn can give insights into the interplay of its functional domains. Result: Spatial distance can be approximated by the graph-distance in RNA secondary structure. We show here that the equilibrium distribution of graph-distances between a fixed pair of nucleotides can be computed in polynomial time by means of dynamic programmi
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