本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。
原文連結
論文資訊
- 類型：已發表論文
- 日期：2014-11-18
摘要
The basic body plan and major physiological axes have been highly conserved during mammalian 演化, yet only a small fraction of the human 基因組 sequence appears to be subject to 演化ary constraint. To quantify cis-versus trans-acting contributions to mammalian regulatory 演化, we performed genomic DNase I footprinting of the mouse 基因組 across 25 cell and tissue types, collectively defining similar to 8.6 million transcription factor (TF) occupancy sites at nucleotide resolution. Here we show that mouse TF footprints conjointly encode a regulatory lexicon that is similar to 95% similar with that derived from human TF footprints. However, only similar to 20% of mouse TF footprints have human orthologues. Despite substantial turnover of the cis-regulatory landscape, nearly half of all pairwise regulat
※ 此為已發表論文，全文需透過期刊付費取得