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原文連結
論文資訊
- 類型：已發表論文
- 日期：2015
摘要
Many macromolecular machines inside the cell exhibit a ‘‘stacked ring’’ architecture, with multiple uniform-length rings of 蛋白質 subunits bound to one another. The majority of these machines must adopt their fully assembled quaternary structure in order to function, making the assembly process vital for cellular function and survival. The assembly of 蛋白質 complexes containing stable substructures has been shown to suffer from a type of kinetic trapping that we term ‘‘assembly deadlock,’’ which occurs when smaller intermediates are exhausted from the system before all of the fully functional structures have formed. Deadlock can result in plateaus in the assembly dynamics, leading to delays in reaching maximum complex assembly and a reduced final complex concentration. While these plateaus hav
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