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原文連結
論文資訊
- 類型：已發表論文
- 日期：2015
摘要
Some researchers in other regions have recommended human papilloma病毒 (HPV) 疫苗接種 to reduce risk of ovarian 癌症, but not in North America, where evidence has previously suggested no role for HPV in ovarian 癌症. Here we use a large sample of ovarian 癌症 transcriptomes (RNA-Seq) from The 癌症 基因組 Atlas (TCGA) database to address whether HPV is involved with ovarian 癌症 in North America. We estimate that a known high-risk type of HPV (type 18) is present and active in 1.5% of cases of ovarian epithelial 癌症s in the US and Canada. Our detection methods were verified by negative and positive controls, and our sequence matches indicated high validity, leading to strong confidence in our conclusions. Our results indicate that previous reports of zero prevalence of HPV in North American cases of ovarian 癌症
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