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原文連結
論文資訊
- 類型：已發表論文
- 日期：2015-01-29
摘要
Within each 細菌l 物種, different strains may vary in the set of genes they encode or in the copy number of these genes. Yet, taxonomic characterization of the human microbiota is often limited to the 物種 level or to previously sequenced strains, and accordingly, the prevalence of intra-物種 variation, its functional role, and its relation to host health remain unclear. Here, we present a comprehensive large-scale analysis of intra-物種 copy-number variation in the gut microbiome, introducing a rigorous 計算 pipeline for detecting such variation directly from shotgun metagenomic data. We uncover a large set of variable genes in numerous 物種 and demonstrate that this variation has significant functional and clinically relevant implications. We additionally infer intra-物種 compositional profiles, identif
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