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原文連結
論文資訊
- 類型：已發表論文
- 日期：2015-01-30
摘要
Phylogenomics heavily relies on well-curated sequence data sets that comprise, for each gene, exclusively 1:1 orthologos. Paralogs are treated as a dangerous nuisance that has to be detected and removed. We show here that this severe restriction of the data sets is not necessary. Building upon recent advances in 數學 系統發育s, we demonstrate that gene duplications convey meaningful 系統發育 資訊 and allow the inference of plausible 系統發育 trees, provided orthologs and paralogs can be distinguished with a degree of certainty. Starting from tree-free estimates of orthology, cograph editing can sufficiently reduce the noise to find correct event-annotated gene trees. The 資訊 of gene trees can then directly be translated into constraints on the 物種 trees. Although the resolution is very poor for individual g
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