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原文連結
論文資訊
- 類型：已發表論文
- 日期：2015-04-16
摘要
Background Safe and effective vaccines could help to end the ongoing Ebola 病毒 疾病 流行病學c in parts of west Africa, and mitigate future outbreaks of the 病毒. We assess the 統計 validity and power of randomised controlled trial (RCT) and stepped-wedge cluster trial (SWCT) designs in Sierra Leone, where the incidence of Ebola 病毒 疾病 is spatiotemporally heterogeneous, and is decreasing rapidly. Methods We projected district-level Ebola 病毒 疾病 incidence for the next 6 months, using a 隨機 model fitted to data from Sierra Leone. We then simulated RCT and SWCT designs in trial 族群s comprising geographically distinct clusters at high risk, taking into account realistic logistical constraints, and both individual-level and cluster-level variations in risk. We assessed false-positive rates and power for parame
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