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原文連結
論文資訊
- 類型：已發表論文
- 日期：2015-06-10
摘要
Peto's paradox is the lack of the expected trend in 癌症 incidence as a function of body size and lifespan across 物種. The leading hypothesis to explain this pattern is 自然選擇 for differential 癌症 prevention in larger, longer lived 物種. We evaluate whether a similar effect exists within 物種, specifically humans. We begin by reanalysing a recently published dataset to separate the effects of stem cell number and replication rate, and show that each has an independent effect on 癌症 risk. When considering the lifetime number of stem cell divisions in an extended dataset, and removing cases associated with other 疾病s or carcinogens, we find that lifetime 癌症 risk per tissue saturates at approximately 0.3-1.3% for the types considered. We further demonstrate that grouping by anatomical site explains most
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