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原文連結
論文資訊
- 類型：已發表論文
- 日期：2015-06-22
摘要
Background: The recent increase in whooping cough incidence (primarily caused by Bordetella pertussis) presents a challenge to both public health practitioners and scientists trying to understand the mechanisms behind its resurgence. Three main hypotheses have been proposed to explain the resurgence: 1) waning of protective immunity from 疫苗接種 or natural infection over time, 2) 演化 of B. pertussis to escape protective immunity, and 3) low vaccine coverage. Recent studies have suggested a fourth mechanism: asymptomatic 傳播 from individuals vaccinated with the currently used acellular B. pertussis vaccines. Methods: Using wavelet analyses of B. pertussis incidence in the United States (US) and United Kingdom (UK) and a phylodynamic analysis of 36 clinical B. pertussis isolates from the US, we f
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