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原文連結
論文資訊
- 類型：已發表論文
- 日期：2015-06-27
摘要
Molecular chaperones fold many 蛋白質s and their mutated versions in a cell and can sometimes buffer the phenotypic effect of 突變s that affect 蛋白質 folding. Unanswered questions about this buffering include the nature of its mechanism, its influence on the 遺傳 variation of a 族群, the fitness trade-offs constraining this mechanism, and its role in expediting 演化. Answering these questions is fundamental to understand the contribution of buffering to increase 遺傳 variation and ecological diversification. Here, we performed experimental 演化, 基因組 resequencing, and 計算 analyses to determine the trade-offs and 演化ary trajectories of Escherichia coli expressing high levels of the essential chaperonin GroEL. GroEL is abundantly present in 細菌, particularly in 細菌 with large loads of deleterious 突變s, suggesting
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