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原文連結
論文資訊
- 類型：已發表論文
- 日期：2015-07-06
摘要
Arthropod-borne 病毒es (arbo病毒es) are maintained in a cycle of alternating 傳播 between vertebrate hosts and arthropod vectors. Arbo病毒es possess RNA 基因組s capable of rapid diversification and 適應, and the between-host trade-offs inherent to host alternation impose well-documented constraints on arbo病毒 演化. Here, we investigate the less well-studied within-host trade-offs that shape arbo病毒 replication dynamics and 傳播. Arbo病毒es generally establish lifelong infection in vectors but transient infection of variable magnitude (i.e. peak 病毒 concentration) and duration in vertebrate hosts. In the majority of experimental infections of vertebrate hosts, both the magnitude and duration of arbo病毒 replication depended upon the dose of 病毒 administered, with increasing dose resulting in greater magnitude but s
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