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原文連結
論文資訊
- 類型：已發表論文
- 日期：2015-08-07
摘要
All 生物 演化 takes place in a space of possible genotypes and their phenotypes. The structure of this space defines the 演化ary potential and limitations of an evolving system. 代謝 is one of the most ancient and fundamental evolving systems, sustaining life by extracting energy from extracellular nutrients. Here we study 代謝's potential for innovation by analyzing an exhaustive genotype-phenotype map for a space of 1015 代謝s that encodes all possible subsets of 51 reactions in central carbon 代謝. Using flux balance analysis, we predict the viability of these 代謝s on 10 different carbon sources which give rise to 1024 potential metabolic phenotypes. Although viable 代謝s with any one phenotype comprise a tiny fraction of genotype space, their absolute numbers exceed 109 for some phenotypes. 代謝s with an
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