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原文連結
論文資訊
- 類型：已發表論文
- 日期：2015-09-07
摘要
RNA 病毒es are the main source of emerging infectious 疾病s because of the 演化ary potential bestowed by their fast replication, large 族群 sizes and high 突變 and recombination rates. However, an equally important property, which is usually neglected, is the topography of the 適應度景觀. How many fitness maxima exist and how well they are connected is especially interesting, as this determines the number of accessible 演化ary pathways. To address this question, we have reconstructed a region of the 適應度景觀 of tobacco etch poty病毒 constituted by 突變s observed during the experimental 適應 of the 病毒 to the novel host Arabidopsis thaliana. Fitness was measured for many genotypes and showed the existence of multiple peaks and holes in the landscape. We found prevailing epistatic effects between 突變s, with cases of re
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