摘要 How 生物 systems such as 蛋白質s achieve robustness to

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論文資訊

• 類型：已發表論文
• 日期：2015-09-21

摘要

How 生物 systems such as 蛋白質s achieve robustness to ubiquitous perturbations is a fundamental 生物 question. Such perturbations include errors that introduce phenotypic 突變s into nascent 蛋白質s during the translation of mRNA. These errors are remarkably frequent. They are also costly, because they reduce 蛋白質 stability and help create toxic misfolded 蛋白質s. Adaptive 演化 might reduce these costs of 蛋白質 mistranslation by two principal mechanisms. The first increases the accuracy of translation via synonymous "high fidelity" codons at especially sensitive sites. The second increases the robustness of 蛋白質s to phenotypic errors via amino acids that increase 蛋白質 stability. To study how these mechanisms are exploited by 族群s evolving in the laboratory, we evolved the 抗生素 resistance gene TEM-1 in Escherichia

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