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原文連結
論文資訊
- 類型：已發表論文
- 日期：2015-10-05
摘要
Although Burkitt lymphomas and follicular lymphomas both have features of germinal center B cells, they are 生物ly and clinically quite distinct. Here we performed whole-基因組 bisulfite, 基因組 and transcriptome sequencing in 13 IG-MYC translocation-positive Burkitt lymphoma, nine BCL2 translocation-positive follicular lymphoma and four normal germinal center B cell samples. Comparison of Burkitt and follicular lymphoma samples showed differential methylation of intragenic regions that strongly correlated with expression of associated genes, for example, genes active in germinal center dark-zone and light-zone B cells. Integrative pathway analyses of regions differentially methylated in Burkitt and follicular lymphomas implicated DNA methylation as cooperating with somatic 突變 of sphingosine phosp
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