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原文連結
論文資訊
- 類型：已發表論文
- 日期：2015-10-21
摘要
Within-host 遺傳 sequencing from samples collected over time provides a dynamic view of how 病毒es evade host immunity. 免疫-driven 突變s might stimulate neutralization breadth by selecting antibodies adapted to cycles of 免疫 escape that generate within-subject epitope 多樣性. Comprehensive identification of 免疫-escape 突變s is experimentally and 計算ly challenging. With current technology, many more viral sequences can readily be obtained than can be tested for binding and neutralization, making down-selection necessary. Typically, this is done manually, by picking variants that represent different time-points and branches on a 系統發育 tree. Such strategies are likely to miss many relevant 突變s and combinations of 突變s, and to be redundant for other 突變s. Longitudinal Antigenic Sequences and Sites from Intrahos
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