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原文連結
論文資訊
- 類型：已發表論文
- 日期：2016
摘要
Despite the recent development of highly effective anti-hepatitis C 病毒 (HCV) drugs, the global burden of this pathogen remains immense. Control or eradication of HCV will likely require the broad application of antiviral drugs and development of an effective vaccine. A precise molecular identification of transmitted/founder (T/F) HCV 基因組s that lead to productive clinical infection could play a critical role in vaccine research, as it has for HIV-1. However, the replication schema of these two RNA 病毒es differ substantially, as do viral responses to innate and adaptive host defenses. These differences raise questions as to the certainty of T/F HCV 基因組 inferences, particularly in cases where multiple closely related sequence lineages have been observed. To clarify these issues and distinguish
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